For Ulcerative Colitis, One Mesalamine a Day is Best

December 12, 2011

FEATURED SEARCH: ulcerative colitis

Two-thirds fewer pills improve results by one-third, at least when it comes to mesalamine and ulcerative colitis, researchers report. Patients with UC who received a once-daily dose of mesalamine had 32% fewer relapses than those taking three pills a day, according to a study presented at the 2011 Digestive Disease Week meeting in Chicago. The reason less is more, in this case, has more to do with human behavior than medical efficacy.

RESULT: Once-daily Mesalamine Better Than Thrice-daily Dosing for UC
Gastroenterology and Endoscopy News | Nov 28, 2011 (FREE FULL TEXT)

In the first meta-analysis to assess dosage effects of mesalamine in ulcerative colitis, British researchers found that doses above 2 mg/day are effective. But doses higher than 2.5 mg/day did not appear to increase the likelihood of remission.

RESULT: Efficacy of 5-Aminosalicylates in Ulcerative Colitis: Systematic Review and Meta-Analysis
American Journal of Gastroenterology | Apr 1, 2011 (Free abstract. Full text $32)

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