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Osteoarthritis

Osteoarthritis

Three eminent rheumatologists have posted their comprehensive textbook of rheumatology online, open-access and free. They are calling it Rheumaknowledgy.

Prompt action by Alabama rheumatologists has caused Blue Cross Blue Shield to rethink a policy denying all claims for injections into knees with osteoarthritis. But a similar "ban" on hyaluronic acid in neighboring Florida takes effect today.

A second biomarker panel shows promise in distinguishing osteoarthritis from rheumatoid arthritis early enough to prevent joint damage. This one relies partly on lack of antibody response to citrullinated proteins in early osteoarthritis.

(AAOS2015) Total knee replacements appear successful for the relatively young and active as well as for those over 90. For people with the most preoperative pain, however, they may not help at all.

(AAOS2015) The first study to assess the effect of steroid injections on the hip joint suggests that they may hasten joint degeneration, but the co-injected local anesthetic is also suspect.

Pfizer and Lilly will resume development of the anti-nerve growth factor monoclonal antibody tanezumab for osteoarthritis pain, after the FDA lifted its ban imposed due to adverse effects in animal trials.

The good news: At best, intraarticular hyaluronate injected into the knee for osteoarthritis (OA) is modestly effective. The bad news: At worst, it’s indistinguishable from placebo, in some meta-analyses.

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