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Osteoarthritis

Osteoarthritis

More careful patient selection is making knee replacement ever safer, judging from data in a huge British registry. But the analysis may generate an unfair bias favoring total over partial replacement.

Pfizer expects to release Embeda (morphine sulfate and naltrexone hydrochloride), approved in 2009 based on osteoarthritis studies but withdrawn by another firm in 2011 due to concerns over abuse, sometime early next year.

Neither needle nor laser acupuncture demonstrate a clinical benefit over placebo in older patients with moderate or severe chronic knee pain.

Overlaps between PsA and OA can produce diagnostic confusion. Multimodality imaging may help sort things out

osteoarthritis

Topical diclofenac and acetaminophen are the best bets for osteoarthritis pain, concludes a review in Medical Letter. Hyaluronic acid scores a moderately favorable vote.

Separate newly published assessments describe hyaluronic acid injections and debridement after meniscectomy of scant clinical value for longstanding relief of knee pain, whatever small statistical significance may turn up in some studies.

The FDA has approved a smaller-particle NSAID formulation that relieves osteoarthritis pain with few adverse effects.

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