Linagliptin achieves significant improvements in glycemic control in a pooled analysis of clinical trials. And a separate randomized trial shows that it can spare insulin and protect kidneys in patients with type 2 diabetes and severe renal insufficiency.
The one single measure that adequately captures the full burden of depression, according to data from the STAR*D study, is the Individual Burden of Illness Index for Depression, which incorporates multidimensional patient-reported outcomes prior to and following treatment.
In children, bilateral otitis media appears to be only slightly more severe than unilateral, according to a study whose authors offer advice on how to judge severity. And a systematic review offers guidance on when to use antibiotics.