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HPV

 

TheBasics

•  Most prevalent sexually transmitted infection in the United States

•  Present in the genital tract of many sexually active individuals

•  Transmitted by direct contact with skin or mucosal surfaces

•  Responsible for genital warts (condyloma acuminata), usually benign

•  Causes about 70% of cervical cancers

•  Increasingly associated with squamous cell carcinoma of the head and neck

•  Occurs in 15 cancer-causing strains; HPV16 and HPV18 are most virulent

•  Vaccines are highly effective in preventing genital intraepithelial neoplasia (cervical and anal)

•  Two vaccines are approved:

                Cervarix (bivalent HPV 16/18) against cervical cancer
                Gardasil (quadrivalent HVP 16/18/6/11) against cervical or anal cancer

 

GUIDELINES

 

Prevention of Human Papillomavirus Infection: Provisional Recommendations for Immunization of Girls and Women with Quadrivalent Human Papillomavirus Vaccine
American Academy of Pediatrics

 

Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP)

 

American Cancer Society Guideline for Human Papillomavirus (HPV) Vaccine Use to Prevent Cervical Cancer and Its Precursors

 

RESOURCES
 

EMedicine:  Human Papillomavirus

 

FDA Licensure of Bivalent Human Papillomavirus Vaccine (HPV2, Cervarix) for use in Females and Updated HPV Vaccination Recommendations from the Advisory Committee on Immunization Practices (ACIP)
CDC Morbidity and Mortality Weekly Reports, May 2010

 

Efficacy and Safety of Prophylactic Vaccines against Cervical  HPV Infection and Diseases among Women:  A Systematic Review & Meta-Analysis
BMC Infectious Diseases, January 2011


Efficacy of Quadrivalent HPV Vaccine against HPV Infection and Disease in Males
New England Journal of Medicine, February 2011

 

Oropharyngeal Cancer Epidemic and Human Papillomavirus
CDC Emerging Infectious Diseases, November 2010


Variables Associated With Human Papillomavirus (HPV) Acceptance by Men
Journal of the American Board of Family Medicine, January 2009

 

TipsandTools


ClinicalTrials

FeaturedArticles

HPV in Head and Neck Cancers: A Useful Bystander?
It's easy to jump to the conclusion that human papillomavirus is behind the rise in head and neck cancers. But a UK study suggests otherwise. More »
Radiology Quiz: Bronchiolitis? Pneumonia? Croup? Epiglottitis?
A 27-month-old girl is brought in for evaluation of hoarseness. She was born at 27 weeks' gestation, and spent... More »
Podcast: Addressing Parents’ Concerns About Vaccinating Boys Against HPV Infection
You and your colleagues are undoubtedly hearing questions from a lot of concerned parents about the new... More »
Podcast: New Guidelines for Vaccinating Boys Against HPV Infection
What exactly are the new guidelines for vaccinating boys against HPV infection—and why is this development good news for... More »
Podcast: New Guidelines for Vaccinating Boys Against HPV Infection
What exactly are the new guidelines for vaccinating boys against HPV infection—and why is this development good... More »
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ResearchandReviews

virtualmentor.ama-assn.org - 1/1/12
www.nature.com - 1/12/12
www.infectagentscancer.com - 11/18/11
www.biomedcentral.com - 12/2/11
sti.bmj.com - 12/1/11
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ArticlesandNews

emedicine.medscape.com - 12/29/11
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infections.consultantlive.com - 6/3/09
www.cdc.gov - 8/26/09
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PubMed

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Evidence-basedResearch

virtualmentor.ama-assn.org - 1/1/12
www.nature.com - 1/12/12
www.infectagentscancer.com - 11/18/11
www.biomedcentral.com - 12/2/11
sti.bmj.com - 12/1/11
www.molecular-cancer.com - 11/11/11
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FromPhysiciansPractice

Physicians Need to Balance Roles at Work Just Like at Home
Jennifer Frank, MD, February 21, 2012
Just like laundry duty and getting the kids dressed for their holiday concert, I take my primary-care responsibility very personally and very seriously.
Motivating and Engaging Your Medical Practice Staff
P.J. Cloud-Moulds, February 18, 2012
Providing autonomy and support will motivate your staff in helping you reach your medical practice goals.
Video: EHR User Satisfaction
Aubrey Westgate, February 17, 2012
Family physician Kenneth Adler, a presenter at the HIMSS12 Conference in Las Vegas, provides a look at national EHR user satisfaction rates.
Understanding Physician Assistant Reimbursement
Stephen Hanson, PA-C, February 17, 2012
Appropriate and fair reimbursement for the work physician assistants do in medicine is a priority.
Five Tips to Better Manage Your Revenue Cycle
Owen Dahl, February 14, 2012
It is vital that practices have systematic ways to address patient collections; the following strategies can help your practice collect all that it is due.

PatientResources

Human Papillomavirus Infection
American College of Obstetricians and Gynecologists

 

Human Papillomavirus Vaccine
American College of Obstetricians and Gynecologists

 

Human Papillomavirus
Centers for Disease Control and Prevention

 

Human Papillomavirus (HPV)
familydoctor.org (American Academy of Family Physicians)

 

HPV
Medline Plus (National Institutes of Health)

 

 

SearchMedicaNews


Even Mild Hamstring Injuries Have a Major Impact in Sports
February 17, 2012

Minor hamstring injuries account for half the time that European football players spend on the bench.

CA-125, KRAS biomarkers make gains in ovarian cancer for disease progression
February 16, 2012

The CALYPSO trial compared CA-125 testing to imaging studies. Another trial finds value in a KRAS variant in judging chemotherapy resistance.

Online CBT Treats Even Severe Comorbid Depression in Diabetes
February 15, 2012

An easier option for treating diabetes in depression, but bad news for those who have it.

Intussusception Discharges Unchanged with Rotavirus Vaccine
February 14, 2012

Does the rotavirus vaccine in increase the risk? Both CDC and FDA warn about the risk of recurrent intussusception, but an analysis of hospital records gives reassurance.

Some Schizophrenia Patients Meet Criteria for Remission
February 10, 2012

Appropriate treatment helps about one in four patients to achieve meaningful outcomes.