The addition of whole-genome sequencing to an infection-control investigation in a special care baby unit enhanced the detection of methicillin-resistant Staphylococcus aureus (MRSA) cases and identification of MRSA transmission into the community. The authors discuss the value of routine real-time use of whole-genome sequencing to detect outbreaks months earlier than identification through clustering of cases.
RESULT: Whole-genome sequencing for analysis of an outbreak of methicillin-resistant Staphylococcus aureus: a descriptive study
Lancet | Feb 1, 2013 (FREE FULL TEXT)
The next generation of genome DNA sequencers is likely to replace conventional culture-based, molecular typing methods, these authors suggest, to provide point-of-care clinical diagnosis and other essential information for quicker, better treatment of patients. They provide a blueprint for how genomic tools could spawn a global system of linked databases to ensure more efficient detection, prevention, and control of infectious disease outbreaks.
RESULT: Integrating Genome-based Informatics to Modernize Global Disease Monitoring, Information Sharing, and Response
Emerging Infectious Diseases | Oct 2, 2012 (FREE FULL TEXT)
Genome Sequencing Shows MRSA Spread into the Community
February 8, 2013
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