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Glucose Control Predicts Nerve Damage in Diabetic Neuropathy

Glucose Control Predicts Nerve Damage in Diabetic Neuropathy

Glycated hemoglobin (HbA1c) levels can be used to predict myelinated nerve fiber regeneration and degeneration in patients with diabetic neuropathy, according to this retrospective examination of a large cohort of patients with changes in sural nerve myelinated fiber density. Maintaining optimal blood glucose control is essential to prevent continued nerve injury among diabetic neuropathy patients, the authors say. 

RESULT:  Identification of Factors Associated With Sural Nerve Regeneration and Degeneration in Diabetic Neuropathy
Diabetes Care | Oct 7, 2013 (Free abstract. Full text $25)

The article below provides a neurobiological explanation for the apparent paradox between decreased sensation and increased sensory phenomena in diabetic polyneuropathies, and strongly endorses screening diabetic feet for 10-g monofilaments to detect sensation loss. The authors explain why tests of tactile and thermal hyperalgesia, as additional markers of neural hyperactivity, can be useful for diagnosis and disease management.

RESULT:  Assessing Decreased Sensation and Increased Sensory Phenomena in Diabetic Polyneuropathies
Diabetes | Nov 1, 2013 (Free abstract. Full text $25)


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