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Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis.
pubmed.gov - 5/15/12
Bevacizumab (BV) is an antivascular endothelial growth factor antibody. When administered with other chemotherapeutic drugs, BV-combined regimens prolong survival of colorectal cancer patients. We conducted a phase II trial to confirm the pharmacokinetic parameters from 3-Tesla dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as surrogate biomarkers of BV + FOLFIRI regimen efficacy in colorectal cancer with liver metastases. DCE-MRI was performed before treatment, on the seventh day after first treatment and every 8 weeks thereafter using a 3-Tesla MRI system. DCE-MRI parameters-area under the contrast concentration versus time curve at 90 and 180 s (AUC90 and AUC180, respectively) after contrast injection, and volume transfer constant of contrast agents (K(trans) and K(ep) ) were calculated from liver metastases. Fifty-eight liver metastases were analyzed. Univariate analysis revealed that a decrease in K(trans) ratios (K(trans) ), K(ep) ratios (K(ep) ), AUC90
Virtual Colonoscopy
www.diagnosticimaging.com - 5/7/12
Virtual colonoscopy news, cases, special reports, and other resources from Diagnostic Imaging, the preeminent online destination for medical imaging professionals.
PLoS ONE: KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer
www.plosone.org - 5/7/12
PLoS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
ASGE: Technology Reviews
www.asge.org - 5/3/12
TechnologyPatient CareEndoscope Design and CareDevicesTechniquesColonoscopyEGDERCPEUSMiscellaneousWhats New:
Cost-effectiveness of informatics and health IT: impact on finances and quality of care
jamia.bmj.com - 5/1/12
of a decision support tool for colorectal cancer screening.

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FeaturedArticles

May 16, 2012
Laxative-Free CT Colonography Finds High-Risk Polyps
A no-prep virtual colonoscopy appears to be as effective as a standard colonoscopy in detecting larger polyps that are more likely to become cancers. More »
May 15, 2012
Genetic Testing: The Bigger Picture
Schrader and colleagues provide four compelling examples of the power of genetic testing to impact medical management for probands and their family members. More »
May 15, 2012
Genetic Testing in Gastrointestinal Cancers: A Case-Based Approach
Indicators that identify individuals who may harbor germline mutations predisposing them to cancer include a family history of multiple cancers that reflect a pattern of disease, young age at onset, multiple primary tumors, tumors with particular histologic phenotypes, the presence of precursor... More »
May 11, 2012
A 54-Year-Old Woman Notes the Abundant Development of Nonpigmented Hair on Her Ears and Nose
A 54-year-old woman, previously in excellent health, noted the insidious development of abundant, thin, and softly textured, nonpigmented hair on her ears and nose. A detailed review of systems was entirely negative, and both a complete blood count and automated routine biochemistry panel were... More »
May 9, 2012
Physical Activity in Cancer Survivors Associated With Better Health Outcomes
A new study from the National Cancer Institute shows that physical activity is associated with lower mortality rates in patients with breast and colon cancers. More »
Showing 1 - 5 of 2,533 results.
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ResearchandReviews

1-3/4 fucosylation at Asn 241 of -haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers.
pubmed.gov - 5/15/12
PLoS ONE: KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer
www.plosone.org - 5/7/12
Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis.
pubmed.gov - 5/15/12
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials : The Lancet Oncology
www.thelancet.com - 5/1/12
Cost-effectiveness of informatics and health IT: impact on finances and quality of care
jamia.bmj.com - 5/1/12
More Results

ClinicalTrials

1-3/4 fucosylation at Asn 241 of -haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers.
pubmed.gov - 5/15/12
PLoS ONE: KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer
www.plosone.org - 5/7/12
Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis.
pubmed.gov - 5/15/12
More Results

PubMed

1-3/4 fucosylation at Asn 241 of -haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers.
pubmed.gov - 5/15/12
PLoS ONE: KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer
www.plosone.org - 5/7/12
Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis.
pubmed.gov - 5/15/12
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials : The Lancet Oncology
www.thelancet.com - 5/1/12
Cost-effectiveness of informatics and health IT: impact on finances and quality of care
jamia.bmj.com - 5/1/12
More Results

ArticlesandNews

1-3/4 fucosylation at Asn 241 of -haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers.
pubmed.gov - 5/15/12
PLoS ONE: KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer
www.plosone.org - 5/7/12
Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis.
pubmed.gov - 5/15/12
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials : The Lancet Oncology
www.thelancet.com - 5/1/12
Cost-effectiveness of informatics and health IT: impact on finances and quality of care
jamia.bmj.com - 5/1/12
More Results


TopicIndex

PracticeGuidelines

1-3/4 fucosylation at Asn 241 of -haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers.
pubmed.gov - 5/15/12
PLoS ONE: KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer
www.plosone.org - 5/7/12
Pharmacokinetic parameters from 3-Tesla DCE-MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis.
pubmed.gov - 5/15/12
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials : The Lancet Oncology
www.thelancet.com - 5/1/12
Cost-effectiveness of informatics and health IT: impact on finances and quality of care
jamia.bmj.com - 5/1/12
Landes Bioscience Journals: Cancer Biology & Therapy
www.landesbioscience.com - 5/1/12
More Results

FromPhysiciansPractice

Physician Performance Goals Are Great, But Balance Is More Realistic
Jennifer Frank, MD,  May 15, 2012
Performance measurements for physicians are well-intentioned and get me to rethink how I practice. But in the end I won't make the goals, so I'll have to go with balance over perfection.
Designing the Perfect Business Card for Your Medical Practice
C. Noel Henley, MD,  May 11, 2012
Does your business card say anything substantive about the valuable work you do in your practice? Here’s how to re-design your next business card for maximum impact and engagement.
Registered Nurses an Ideal Fit for Primary Care Practices
Audrey "Christie" McLaughlin, RN,  May 10, 2012
Here are four good reasons to hire a registered nurse for your primary care practice …maybe even instead of a medical assistant.
The Five Biggest Medical Practice Marketing Mistakes
James Doulgeris,  May 10, 2012
There are best practices to marketing your practice, but often, success is more about knowing what not to do. Here are the five most common pitfalls …and how to avoid them.
Can You Practice Medicine and Manage Your Practice?
Rosemarie Nelson,  May 9, 2012
Whether you practice alone, or in a group, if you're trying to see patients in this pay-for-volume environment and also run the business of your practice, you may be missing out on important opportunities.


PatientResources

American Cancer Society
Colorectal Cancer


National Cancer Institute
Colon Cancer
Rectal Cancer
 

National Comprehensive Cancer Network
Guidelines for Patients - Colon Cancer