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Genetic Factors Modify HDL Cholesterol and Lipid Levels in Diabetes

Genetic Factors Modify HDL Cholesterol and Lipid Levels in Diabetes

Genome-wide association studies have identified genetic variants that are associated with high-density lipoprotein cholesterol (HDL-C) or triglyceride levels. Now, for the first time, a study has identified genetic variants that modify lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The authors note that the effects of genetic factors on lipid changes may differ from the effects on baseline lipids.

RESULT: Do Genetic Modifiers of High-Density Lipoprotein Cholesterol and Triglyceride Levels Also Modify Their Response to a Lifestyle Intervention in the Setting of Obesity and Type-2 Diabetes Mellitus?
Circulation: Cardiovascular Genetics | Aug 20, 2013 (Free abstract. Full text $20)

These authors investigated the biological pathways and individual genes behind low HDL-C levels. They found genetic variants within inflammatory pathways and also that the expression of these pathways is upregulated in adipose tissue, according to a population-based study. The authors note that the focal point of these inflammatory pathways seems to be the HLA region, with its  alleles that are associated with low HDL levels..

  Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.
Arteriosclerosis, Thrombosis, and Vascular Biology | Apr 1, 2013 (Free abstract. Full text $20)


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