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FGFs Emerging as Cardiovascular Biomarkers

FGFs Emerging as Cardiovascular Biomarkers

More evidence links fibroblast growth factors to atherosclerosis: In this study of coronary angiography assessments, decreased serum levels of fibroblast growth factor 19 (FGF 19) among coronary artery disease patients correlated with more severe coronary lesions. FGF 19 levels were positively correlated with levels of high-density lipoprotein cholesterol and adiponectin.

  Serum Levels of Fibroblast Growth Factor 19 Are Inversely Associated with Coronary Artery Disease in Chinese Individuals
PLoS One | Aug 7, 2013 (FREE FULL TEXT)

These researchers found in a study of carotid intima media thickness that another fibroblast growth factor, FGF-21, was significantly associated with the presence of carotid atherosclerosis, independent of adverse lipid profiles and C-reactive protein. The 670 subjects were from southern China.

RESULT:  Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors
Arteriosclerosis, Thrombosis, and Vascular Biology | Jul 18, 2013 (Free abstract. Full text $20)

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