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Elevated C-reactive Protein Increases Risk of Late-onset Bipolar Disorder

Elevated C-reactive Protein Increases Risk of Late-onset Bipolar Disorder

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Evidence is growing that bipolar disorder is associated with inflammation, including abnormal levels of acute-phase C-reactive protein (CRP), which may play a role in late-onset bipolar disorder.

These authors tested whether elevated levels of CRP are associated with late-onset bipolar disorder in cross-sectional and prospective analyses. They followed 78,809 individuals from the general population for a median of 5.9 years, noting genetic variants influencing CRP levels.

They found that elevated CRP levels were associated both cross-sectionally and prospectively with late-onset bipolar disorder. A doubling in CRP yielded an observational odds ratio for late-onset bipolar disorder of 1.28 with a corresponding causal odds ratio of 4.66.

In conclusion, the authors stated that their genetic analysis supports the association of elevated CRP with increased risk of late-onset bipolar disorder in the general population. Therefore, the measurement of CRP level might be relevant to the clinical care of bipolar disorder patients.

Result: Elevated C-reactive protein and late-onset bipolar disorder in 78,809 individuals from the general population. British Journal of Psychiatry| Feb 1, 2016 (Free abstract. Full text $30)

 

 
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