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Common medical conditions frequently complicate bipolar disorder. The purely physical problems often receive more attention and care than the mood disorder.

There is increasing evidence that diabetes or prediabetes may contribute to the risk for bipolar, as well as interfering with treatment effectiveness.

Recovery-focused cognitive behavior therapy is showing promise in reducing recent-onset bipolar disorder.

New research is clarifying the link between brain glutamate levels and risk for psychosis in bipolar, as well as genes associated with the glutamate pathway that are overexpressed in bipolar.

Deficits in dopamine signaling are linked strongly to poor decision making in patients with bipolar. Is it time to stratify treatment based on this understanding?

Three studies investigate patterns of substance abuse among patients with bipolar disorder, and agents that may help.

Treating bipolar with lithium at its earliest onset increases the odds of success. However, vigilance for toxicities is in order, as two recent case studies demonstrate.

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